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Responsible and judicious anabolic steroid use among healthy adult males is a significantly different situation in comparison to anabolic steroid use among children, teenagers, and females(e.g. ). Most likely the problem is in the early adolescent period when the drug use is still immature. This may be a more pronounced instance of misusing the drug (eg. ) as it has been also found in children , particularly with the misuse of marijuana. Children also show lower testosterone levels  and may be more sensitive to anabolic steroids. This may be a more important factor in the problem of nonlinear development than the age-related differences in testosterone . In adults, the problem of nonlinearity may be related to the development of the pituitary gland as a result of early puberty. It is known for example that early puberty has an impact on the pituitary gonadotropin rhythm, which is a crucial event for a balanced and adequate testosterone production. This is in line with the fact that nonlinear and abnormal pituitary hormone rhythm (eg. high or low levels of luteinizing hormone) has been reported to be very common in the male adolescents in the US . In the study of Adair et al.  the use of nonanabolic steroids and a history of abnormal pituitary hormones were strongly associated with an accelerated rate of puberty compared to healthy males. This effect is related to a greater development of the pituitary gland and increased testosterone production and also may be associated with increased incidence of cancer. In addition to being affected by nonlinearity, early puberty may also result in a greater incidence of cancer. The use of nonanabolic steroids and a history of abnormal pituitary hormones are not only associated with an increased occurrence of cancer, but also with an increased odds in developing cancer . It is generally agreed that the use of nonanabolic steroids as they relate to the treatment of male pattern baldness could increase the risk for nonmelanoma skin cancer. Since nonanabolic steroids are known to have an influence on breast and prostate cancer risk, some may consider it as an alternative to estrogen therapy in this aspect as they can be available in pharmacies or the doctor. However it is important to discuss how these drugs would relate to the body's own cancer resistance system. However, the authors also concluded that "the results from this study highlight the need for further research into possible differences and interactions between anabolic androgenic steroids and other risk factors including environmental, lifestyle, and genetic factors for cancer" . In a study published by the National Cancer Institute (NCI) [10 Similar articles: